LymphedemaV1, Main, Exploration, bibRecord, 007744

Lymphangiogenesis in development and disease

Identifieur interne : 007744 ( Main/Exploration ); précédent : 007743; suivant : 007745

Lymphangiogenesis in development and disease

Auteurs : Ruediger Liersch [Allemagne] ; Michael Detmar [Suisse]

Source :

Thrombosis and haemostasis [ 0340-6245 ] ; 2007.

RBID : Pascal:07-0393202

Descripteurs français

KwdFr :
- Animaux, Développement embryonnaire, Humains, Inflammation, Lymphangiogenèse (physiologie), Métastase tumorale, Tumeurs.
MESH :
- physiologie : Lymphangiogenèse.
Pascal (Inist)
- Animaux, Développement embryonnaire, Humains, Inflammation, Lymphoedème, Métastase tumorale, Système lymphatique, Endothélium, Tumeur maligne, Inflammation, Métastase, Lymphangiogenèse, Cancer, Tumeurs.
Wicri :
- topic : Cancer.

English descriptors

KwdEn :
- Animals, Cancer, Embryonic Development, Endothelium, Humans, Inflammation, Lymphangiogenesis, Lymphangiogenesis (physiology), Lymphatic system, Lymphedema, Malignant tumor, Metastasis, Neoplasm Metastasis, Neoplasms.
MESH :
- physiology : Lymphangiogenesis.
- Animals, Embryonic Development, Humans, Inflammation, Neoplasm Metastasis, Neoplasms.

Abstract

The lymphatic vascular system plays an important role in the maintenance of fluid homeostasis, in the afferent immune response, in the intestinal lipid uptake and in the metastatic spread of malignant cells.The recent discovery of specific markers and growth factors for lymphatic endothelium and the establishment of genetic mouse models with impairment of lymphatic function have provided novel insights into the molecular control of the lymphatic system in physiology and in embryonic development. They have also identified molecular pathways whose mutation-al inactivation leads to human diseases associated with lymphedema. Moreover, the lymphatic system plays a major role in chronic inflammatory diseases and in transplant rejection. Importantly, malignant tumors can directly promote lymphangiogenesis within the primary tumor and in draining lymph nodes, leading to enhanced cancer metastasis to lymph nodes and beyond. Based upon these findings, novel therapeutic strategies are currently being developed that aim at inhibiting or promoting the formation and function of lymphatic vessels in disease.

Affiliations:

Le document en format XML

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<term>Lymphatic system</term>
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<term>Malignant tumor</term>
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<front><div type="abstract" xml:lang="en">The lymphatic vascular system plays an important role in the maintenance of fluid homeostasis, in the afferent immune response, in the intestinal lipid uptake and in the metastatic spread of malignant cells.The recent discovery of specific markers and growth factors for lymphatic endothelium and the establishment of genetic mouse models with impairment of lymphatic function have provided novel insights into the molecular control of the lymphatic system in physiology and in embryonic development. They have also identified molecular pathways whose mutation-al inactivation leads to human diseases associated with lymphedema. Moreover, the lymphatic system plays a major role in chronic inflammatory diseases and in transplant rejection. Importantly, malignant tumors can directly promote lymphangiogenesis within the primary tumor and in draining lymph nodes, leading to enhanced cancer metastasis to lymph nodes and beyond. Based upon these findings, novel therapeutic strategies are currently being developed that aim at inhibiting or promoting the formation and function of lymphatic vessels in disease.</div>
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Serveur d'exploration sur le lymphœdème

Lymphangiogenesis in development and disease

Lymphangiogenesis in development and disease

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Serveur d'exploration sur le lymphœdème
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